Koplik's spots are associated with which disease?

Koplik's spots are specific mucosal lesions that are classic for measles. These spots typically appear as small, irregularly shaped, bluish-white spots with a red halo, found on the inner lining of the cheeks. They usually present a few days before the characteristic measles rash appears. The presence of Koplik's spots is often considered a pathognomonic sign for measles, meaning that when they are observed in conjunction with other signs and symptoms of the infection, they strongly indicate that the patient has measles.

In contrast, the other conditions listed do not feature Koplik's spots as a prominent clinical sign. Poxvirus infections, Kawasaki's disease, and Reye's syndrome are linked to distinct symptoms and clinical presentations that do not include these specific oral lesions. Thus, recognizing Koplik's spots helps healthcare providers diagnose measles accurately and facilitates timely intervention, important for preventing complications associated with this viral illness.